Convenience of one prescription and one dosing schedule with a clarithromycin–free regimen1
All-in-one proprietary formulation for simple dosing2
Each Talicia capsule contains2:
10.3 mg omeprazole magnesium,
250 mg amoxicillin, and 12.5 mg rifabutin
Capsule shown not actual size.
Maintains antibiotic exposure
at the site of infection for >90% of a
24-hour period2
Only Talicia contains 2 antimicrobials with zero-to-minimal H. pylori resistance, which may lead to greater eradication success3
Talicia
Other H. pylori antibiotics
Available generic formulations are not therapeutically equivalent to the low-dose rifabutin component of Talicia2
Simple Dosing
Dosing instructions for Talicia
capsules
daily
- Advise patients to take 4 Talicia capsules at least 4 hours apart (eg, morning, midday, and evening) with food
- Talicia should be swallowed with 8 ounces of water
- Patients should not crush or chew capsules
- Advise patients not to take Talicia with alcohol
Pharmacokinetic Profile
PBPK modeling demonstrates that Talicia maintains intragastric rifabutin concentrations ≥H. pylori MIC90 for >90% of a 24-hour period2
MIC90=minimum inhibitory concentration; PBPK=physiologically based pharmacokinetic.
References: 1. TALICIA Prescribing Information. RedHill Biopharma Inc.; 2024. 2. Howden CW, Shah S, Pendse SN, Offman E, Almenoff JS, Sheldon KL. Physiologically-based pharmacokinetic modelling to predict intragastric rifabutin concentrations in the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther. 2023;58(2):159-167. 3. Graham DY, Canaan Y, Maher J, Wiener G, Hulten KG, Kalfus IN. Rifabutin-based triple therapy (RHB-105) for Helicobacter pylori eradication: a double-blind, randomized, controlled trial. Ann Intern Med. 2020;172(12):795-802.