Talicia contains omeprazole, a proton pump inhibitor (PPI), amoxicillin, a penicillin-class antibacterial, and rifabutin, a rifamycin antibacterial. It is contraindicated in patients with known hypersensitivity to any of these medications, any other components of the formulation, any other beta-lactams or any other rifamycin.

Talicia is contraindicated in patients receiving rilpivirine-containing products.

Talicia is contraindicated in patients receiving delavirdine or voriconazole.

Serious and occasionally fatal hypersensitivity reactions have been reported with omeprazole, amoxicillin and rifabutin.

Clostridioides difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents and may range from mild diarrhea to fatal colitis.

Talicia may cause fetal harm. Talicia is not recommended for use in pregnancy.

Talicia may reduce the efficacy of hormonal contraceptives. An additional non-hormonal method of contraception is recommended when taking Talicia.

Talicia should not be used in patients with hepatic impairment or severe renal impairment.

Acute Interstitial Nephritis has been observed in patients taking PPIs and penicillins.

Cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) have been reported in patients taking PPIs. These events have occurred as both new onset and exacerbation of existing autoimmune disease.

The most common adverse reactions (≥1%) were diarrhea, headache, nausea, abdominal pain, chromaturia, rash, dyspepsia, oropharyngeal pain, vomiting, and vulvovaginal candidiasis.

Talicia is H. pylori therapy designed
with patients in mind

Talicia combines all three medications in an all-in-one capsule — that means patients will have to manage only one prescription, one dosing schedule, and one co-pay.

Talicia is H. pylori therapy designed with patients in mind

Talicia combines all three medications in an all-in-one capsule – that means patients will have to manage only one prescription, one dosing schedule, and one co-pay.

Patients should be instructed to take 4 capsules, every 8 hours with food for 14 days.

Capsules should be swallowed whole with a full glass of water and not chewed or crushed. Talicia should not be taken with alcohol.

It is very important for patients to complete the full 14 days of therapy. Just because symptoms are gone does not mean that H. pylori has been eradicated, and patients should be encouraged to complete treatment. Consistent with the ACG guidelines, it is also recommended that testing to prove H. pylori eradication should be performed 1 month after completion of Talicia therapy.

Patients can now download the Talicia Dosing Reminder App